What is Trazodone?

Trazodone is an oral antidepressant medication used to treat depression and other mental health conditions such as anxiety, panic disorder, and post-traumatic stress disorder (PTSD). Trazodone belongs to a class of medications called serotonin modulators, which means it alters the function of serotonin in the body. Serotonin is an important message-sending chemical in the brain. By modifying the way serotonin works, trazodone helps people manage the symptoms of depression.

How Does Trazodone Work?

Trazodone works by blocking the serotonin transporter (SERT) in the brain. SERT is responsible for the reuptake of serotonin, a neurotransmitter believed to be related to feelings of wellbeing, to nerve endings and cells. By blocking SERT, more serotonin is available in the brain, which helps improve mood and reduce anxiety. Trazodone also increases melatonin levels in the body, which helps regulate sleep patterns. Because of this, trazodone is approved for the treatment of insomnia.

Uses, Dosage, and Side Effects

Trazodone is prescribed primarily as an antidepressant, with additional benefit for insomnia and anxiety. The dosage of trazodone ranges from 50 mg to 400 mg, depending on the individual. Common side effects include nausea, headache, dizziness, dry mouth, drowsiness, and decreased libido. Trazodone can also cause weight gain and, in rare cases, increased levels of serotonin can result in a condition called serotonin syndrome. This condition can be serious and usually occurs when two medications that increase serotonin levels are taken together.

Trazodone is a powerful medication that can be very helpful in controlling depression and anxiety. However, it is important to talk to a doctor before beginning treatment. The doctor can help assess the patient’s situation and determine the best treatment plan, as well as help manage potential side effects.